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Cannabidiol: Promise and Pitfalls Over the past few years, increasing public and political pressure has supported legalization of medical marijuana. One of the main thrusts in this effort has Premium Jane has a wide range of CBD hemp oil for sale. You can go to the official PJ website to see what CBD hemp oil products are on offer. The best CBD Oil is now on sale at Diamond. Buy hemp infused CBD oil for rest, relaxation, wellness, and so much more! Be a new you with cannabidiol.

Cannabidiol: Promise and Pitfalls

Over the past few years, increasing public and political pressure has supported legalization of medical marijuana. One of the main thrusts in this effort has related to the treatment of refractory epilepsy—especially in children with Dravet syndrome—using cannabidiol (CBD). Despite initiatives in numerous states to at least legalize possession of CBD oil for treating epilepsy, little published evidence is available to prove or disprove the efficacy and safety of CBD in patients with epilepsy. This review highlights some of the basic science theory behind the use of CBD, summarizes published data on clinical use of CBD for epilepsy, and highlights issues related to the use of currently available CBD products.

Cannabidiol is the major nonpsychoactive component of Cannabis sativa. Over the centuries, a number of medicinal preparations derived from C. sativa have been employed for a variety of disorders, including gout, rheumatism, malaria, pain, and fever. These preparations were widely employed as analgesics by Western medical practitioners in the 19 th century (1). More recently, there is clinical evidence suggesting efficacy in HIV-associated neuropathic pain, as well as spasms associated with multiple sclerosis (1).

Basic Pharmacological Mechanisms

Cannabidiol pharmacological effects are mediated through G protein coupled receptors, cannabinoid type I (CB1) and cannabinoid type II (CB2), which are highly expressed in the hippocampus and other parts of the central nervous system (2). When activated, CB1 receptors inhibit synaptic transmission through action on voltage-gated calcium and potassium channels, which are known to modulate epileptiform and seizure activity (3). CB2 receptors are primarily expressed in the immune system and have limited expression in the central nervous system. The effects of CBD are CB2 receptor independent (3).

Studies have demonstrated that CBD has a low affinity for the CB1 receptors, but even at low concentrations, CBD decreases G-protein activity (3). CB1 receptors are expressed on many glutamatergic synapses that have been implicated in seizure threshold modulation. CBD may act at CB1 receptors to inhibit glutamate release (4). Studies have shown changes in the expression of CB1 receptors during epileptogenesis and after recurrent seizures (5). CB1 receptor expression is upregulated at GABAergic synapses and shown to be downregulated at glutamatergic synapses in epilepsy, contributing to lowering seizure thresholds.

Other targets for CBD include transient receptor potential (TRP) channels that are involved with the modulation of intracellular calcium (1, 6). Cannabinoids are highly lipophilic, allowing access to intracellular sites of action, resulting in increases in calcium in a variety of cell types including hippocampal neurons. CBD actions on calcium homeostasis may provide a basis for CBD neuroprotective properties.

Evidence in Animal Models

When administered alone, CBD is an effective anticonvulsant in maximal electrical shock (MES), magnesium-free, 4-aminopyridine, and audiogenic models (7, 8). Co-administration with AEDs leads to various effects; anticonvulsant effects of CBD are enhanced with phenytoin or phenobarbital but decreased with chlordiazepoxide, clonazepam, trimethadione, and ethosuximide. In a recent study using an acute pilocarpine model, although CBD administration reduced the number of animals displaying seizure activity, CBD did not appear to have any significant effect on the number of seizures per animal (7).

Clinical Evidence in Epilepsy

While animal experimental data clearly suggest a potential benefit, supportive clinical data are quite sparse. In a case-control study of 308 cases of new onset seizures, Brust and colleagues found that marijuana use was significantly less prevalent among men who had unprovoked seizures compared to case controls (9). This difference was not significant in women. The authors suggest a potential protective effect against seizures with marijuana use; however, this should be considered speculative.

A survey of patients seen in a tertiary epilepsy center found that 21% of patients admitted to using marijuana in the last year, and 24% of patients believed marijuana to be effective for their seizures (10). While interesting, this anecdotal observation does not rise to the level of evidence needed to evaluate a potential new therapeutic modality.

Gloss and Vickrey conducted a Cochrane systematic review of the use of CBD in the treatment of epilepsy (11). Their methodology included only those trials that were randomized and controlled and excluded case series, case reports, and expert opinion. They were able to identify only 4 randomized controlled studies reported in the literature, and they included a letter to the editor and an abstract. The total number of subjects enrolled in these studies was 48 (11–14). While only four studies and a letter to the editor were in the actual analysis, the authors included a complete reference listing of all articles reviewed for inclusion.

These reports suffered from a number of design flaws, including incomplete baseline quantification of baseline seizure frequency, indeterminate time periods for outcome determination and, in some cases, inadequate (or missing) statistical analysis—in general, a lack of sufficient detail to adequately evaluate and interpret the findings. Limitations aside, several studies did report that administration of adjunctive CBD did not result in meaningful changes in seizure frequency (11–13).

Cunha et al. reported a 2-phase pilot study of CBD versus placebo in normal volunteers and patients with refractory secondarily generalized epilepsy (14). In the first phase, 8 normal volunteers received CBD or placebo in a doubled-blind fashion, at a dose of 3 mg/kg for 30 days. The second phase was also double-blinded in 15 patients with epilepsy receiving 200 to 300 mg daily of CBD or placebo for 135 days. Patients continued baseline AED. All subjects tolerated CBD well, with no serious adverse events. Four of the epilepsy patients receiving CBD were “almost free of convulsive crisis” for the duration of the study. Three other patients receiving CBD had a partial reduction in seizures, and 1 subject had no response. Of the 7 patients receiving placebo, seizure frequency was unchanged in 6, and 1 had clear improvement in seizure control.

Using rigorous review methodology, Gloss and Vickery conclude that based on the low quality of the reports available, there is insufficient data available to draw any conclusions regarding the efficacy and or long-term safety of CBD in treating epilepsy (11). From the data available, it does appear that daily doses of 200 to 300 mg were safe in this small group of patients for a short period of time (14).

Tolerability and Drug Interactions

CBD is well tolerated in humans with doses up to 600 mg not resulting in psychotic symptoms (15). In the few small placebo-controlled studies performed, no significant CNS effects were noted. Oral CBD undergoes extensive first-pass metabolism via CYP3A4, with a bioavailability of 6%. Following single doses in humans, the half-life of CBD when taken orally is about 1 to 2 days.1 In vitro studies have shown that CBD is a potent inhibitor of multiple CYP isozymes, including CYP 2C and CYP3A (16, 17). Whether these in vitro observations are relevant at plasma concentrations likely to be seen in patients is unclear. In addition, given its metabolism via CYP3A4, clinical trials of CBD in patients receiving enzyme-inducing AEDs, such as carbamazepine or phenytoin, will require detailed pharmacokinetic studies.

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A number of difficulties exist in evaluating published data on CBD or marijuana use for epilepsy. The extremely limited published studies were small, poorly described, and not well designed. Contributing to the difficulty of interpreting published studies, CBD products are not produced under the guidance of good manufacturing practices (GMP) and are not subject to regulations governing labeling, purity, and reliability. In other words, currently, there is no guarantee of consistency between products, or even differing lots produced by the same manufacturer. Without independent testing (e.g. USP certification) of CBD products for content and purity, as well as bioavailability testing of specific products, uncertainty surrounds the use of available CBD products in routine clinical settings.

Conclusions

At this time, there does seem to be a growing body of basic pharmacologic data suggesting there may be a role for CBD, especially in the treatment of refractory epilepsy. However, given the lack of well-controlled trials, we must also ask if we are getting ahead of ourselves. Clearly, this is an emotionally and politically charged issue. If this were any other uninvestigated pharmaceutical compound, would we feel as compelled to make the agent widely available before statistically valid class 1 evidence was available for review? Until data from well-designed clinical trials are available and reliable, and standardized CBD products that are produced using GMP are available, caution must be exercised in any consideration of using CBD for the treatment of epilepsy. In the meantime, based upon promising preliminary data, further clinical research should be wholeheartedly pursued.

CBD Oils

Premium Jane provides CBD hemp oil online, which is extracted from hemp grown in the United States. All of our products come with third-party lab reports. These certificates of analysis show that each item is free from solvents, contaminants, and other harmful chemicals.

We use a Hexane extraction process that removes the cannabinoids from the hemp along with unwanted substances. The result is maximum CBD concentration with minimal THC.

High CBD Hemp Oil for Sale

The CBD-rich hemp oil for sale on the official Premium Jane website comes in various sizes and concentrations. For newcomers to the market or those who want to use a smaller amount, we have bottles containing 300mg and 600mg of CBD. Choose between 10mg of CBD or 20mg of CBD per ml.

If you are looking for a higher CBD concentration, check out our 1000mg range, which comes in a truly delicious Mint Chocolate flavor. However, many of our customers can’t get enough of the Mint, Citrus, or Natural flavors.

Few brands in the industry can match our 3,000mg and 5,000mg CBD products. These come in Lemon Lime flavor and our brand-new Peach Nectar offering. With 83.33mg of CBD per ml, these products are ideal for those who like to use a large level of CBD each day.

Finding Hemp Oil Online

There is hemp oil for sale on an enormous number of websites. However, we recommend sticking with Premium Jane. We are a well-respected and trusted name in the industry. Our loyal customers know we extract our CBD from Kentucky-grown hemp and believe they are getting the best the industry has to offer.

Order Hemp Oil Online

A significant majority of hemp oil sales happen online these days. You can enjoy the convenience of having top-quality CBD delivered to your door. We do our best to ship it as soon as possible, so order today and discover what CBD, and Premium Jane, can do for you.

CBD Hemp Oil FAQ

What Is the Difference Between Hemp Oil & CBD Oil?

There is some confusion over both substances, with the terms often being used interchangeably. As it happens, the primary difference between hemp oil and CBD oil is the cannabidiol content. Also known as hemp seed oil, hemp oil is created through the cold pressing of hemp seeds. In contrast, CBD oil is created by extracting the cannabinoid from the flowers, stalks, stem, and leaves of a hemp plant.

The seeds of the hemp plant have minimal CBD. Therefore, hemp seed oil contains practically no CBD. It is typically used as a food supplement and can be added to salads etc. Do not purchase hemp seed oil if your goal is to consume CBD. The CBD oil you buy from Premium Jane contains a large amount of cannabidiol.

How Much CBD Is in Hemp Oil?

That depends on the brand and whether you’re buying CBD oil or hemp seed oil. The latter contains trace amounts of cannabidiol at best. High-quality brands that sell CBD oil, such as Premium Jane, clearly outline the CBD content on the label and third-party lab reports.

Our hemp CBD oil range contains anywhere from 300mg of CBD to over 5,000mg in a container. The concentration of CBD ranges from 10mg per ml to 83.33mg per ml. No matter what, make sure the CBD product you buy comes with full third-party lab reports.

What Is CBD Hemp Oil Used for?

It depends on the user! Please note that no CBD product should claim to treat, cure, or help diagnose any medical condition, disease, or ailment. Instead, users should consume CBD as part of a routine to help with everyday wellness. Customers use CBD hemp oil for various reasons. These include managing daily stresses, attaining a sense of calm or focus, or assisting with a better sleep cycle.

How to Use CBD Hemp Oil

In most cases, CBD hemp oil users place a few drops of the product beneath their tongue. They hold it there for 60-90 seconds before swallowing. The goal is to ensure the CBD is consumed via the sublingual gland, which lies beneath the tongue. However, some of our customers add their CBD hemp oil to food or beverages.

Which Is Better, CBD Oil or Hemp Oil?

There is no ‘right’ or ‘wrong’ answer to this question. People use CBD hemp oil and hemp seed oil for different purposes. As we mentioned above, our customers use CBD oil for various reasons.

Hemp seed oil contains practically no CBD. However, it does include omega-6 and omega-3 fatty acids, gamma-linolenic acid, various antioxidants, and several vitamins. Users of hemp seed oil tend to include it as part of their daily diet. Of course, high-quality CBD oil also contains fatty acids and other things found in hemp seed oil.

What Is CBD Hemp Oil Good for?

The answer will change depending on what a user is hoping for. For some of our customers, CBD hemp oil is an option for managing everyday stresses. For others, it enables them to achieve a sense of relaxation and calm. Some people believe that CBD hemp oil helps them follow a more regular sleep and wake cycle.

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Where to Buy CBD Hemp Oil Online?

There are an extraordinary number of websites that sell CBD hemp oil online. This includes a large number of third-party vendors. However, we fervently believe that the official Premium Jane website is the best place to start and end your search. Every one of our products comes from high-quality, American-grown hemp.

Also, each product includes a certificate of analysis. This outlines the cannabinoid content and proves that the product is free from pesticides, herbicides, and other harmful chemicals.

How Long Does CBD Hemp Oil Stay in Your System?

There is no definitive answer to this question. Typically, the CBD in hemp oil could remain in your system for 2 – 5 days. However, the duration depends on the amount used, a user’s body mass index & metabolism, the method of use, and other factors.

For instance, vaporized CBD tends to take effect quickly, but its effects also subside more rapidly than with CBD hemp oil or topicals, for instance. Whether a person consumes cannabidiol on an empty stomach or not also affects. In general, CBD taken on an empty stomach is metabolized and eliminated from the body faster than if you use it with a full stomach. This is because the food in your stomach slows down CBD’s digestion.

Premium Jane is dedicated to delivering the natural benefits of CBD to those who truly need it. Join our community and become part of the CBD family!

This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A doctor’s advice should be sought before using any hemp products. All trademarks and copyrights are property of their respective owners and not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.

CBD Oil

The best CBD Oil is now on sale at Diamond. Buy hemp infused CBD oil for rest, relaxation, wellness, and so much more! Be a new you with cannabidiol.

Customer Reviews

Carl W.
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Jennifer J.

This is the best sleep aid I have ever tried. I highly recommend a dropper full and you won’t have to count sheep. Takes about an hour. I wake up refreshed and alert.

Common Questions

Does CBD oil work?

Yes, CBD oil does work! CBD oil works in conjunction with the endocannabinoid system. Because CBD is a cannabinoid, it helps supplement the bodys natural cannabinoids, strengthening the endocannabinoid system. In other words, the endocannabinoid system is a vast system of cannabinoid receptors. Furthermore, the body itself produces its own natural cannabinoids. CBD oil or cannabidiol, in general, is known as a phytocannabinoid (plant-based cannabinoid) that can help to supplement the endocannabinoid system (ECS).

What is cbd oil?

CBD, also known as cannabidiol oil is one of many cannabinoids found in cannabis.Cannabis is the genus name for both marijuana and hemp, and the term itself is not necessarily interchangeable with marijuana. In fact, almost all CBD oil today comes from industrial hemp, which contains negligible amounts of THC, the cannabinoid responsible for causing a high. Most strains of agricultural hemp are rich in CBD while only having less than 0.03 percent THC, making them perfect for extracting CBD oil.

Do you have a CBD dosage chart I can follow?

Yes, for best results with your CBD oil or other CBD products, follow this chart based on your weight: 241lbs Desired Effect Mild 4.5mg 6mg 9mg 12mg 18mg 22.5mg Strong 6mg 9mg 12mg 15mg 22.5mg 30mg Extreme 9mg 12mg 15mg 18mg 27mg 45mg

How do I determine a CBD tincture dosage?

The best way to do this is to simply apply it under the tongue where it is then absorbed into the bloodstream.For maximum effect, let the CBD oil set for as long as possible in order for maximum After a couple of minutes you can then swallow. To determine exactly how much CBD is in a droppers worth of oil, utilize the following formula:[TOTAL CBD IN BOTTLE] [NUMBER OF MILLILITERS IN BOTTLE] = MGS OF CBD PER DROPPERFor example, if you have a bottle of 30mL CBD tincture that contains 1500mg of CBD:1500MG 30ML = 50MG CBD PER DROPPERWhile, this method may not be 100 percent accurate, it is far more accurate than not measuring at all. And remember, always start small and work your way up.

What does cbd oil do?

CBD oil helps with many things from sleep to anxiety ton restlessness to more! It is the perfect hemp compound for your daily wellness routine!

Drop Into Wellness With CBD Oil

CBD Oil for rest, relaxation, and wellness — these are, perhaps, the most well-known uses for the most popular cannabinoid to come from hemp since the discovery of hemp itself. Sure, you’ve heard the terms CBD Oil and CBD Tincture used interchangeably, But are they the same? And when looking to boost your wellness regimen at Diamond CBD, what’s the best CBD Oil to add to your daily routine?

Let’s take a look.

CBD Oil is most often a blend of CBD extract and a ‘carrier’ oil like hemp or coconut oil.

CBD Tincture, on the other hand, is an alcohol-based extract. Using high-proof alcohol as a solvent to extract CBD from cannabis may leave the tincture with a bitter taste, so additives like sweeteners or glycerin are usually mixed to make the product more palatable.

But before we dive into the details about CBD Oil, let’s go back to the beginning. Cannabidiol, or CBD, is an active compound commonly extracted from cannabis plants. While both marijuana and hemp fall under the genus name “cannabis,” the two terms are not interchangeable. Although related, marijuana and hemp are two completely different plants — the most notable difference being their THC content. Unlike tetrahydrocannabinol (THC), CBD doesn’t cause psychoactive effects — it won’t get you high.

Nowadays, almost all CBD Oil comes from industrial hemp, which contains minute amounts of THC while simultaneously being rich in CBD.

How Diamond Manufactures CBD Oil

Diamond CBD keeps a close eye on the CBD Oil production process from cultivation to testing. Sourced from all-natural, all-American industrial hemp, we craft our CBD Oil to ensure reliance, efficiency, and convenience for all users. Our products are third-party tested, certified safe and pure.

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Maintaining absolute transparency about all ingredients, Diamond CBD’s products are guaranteed to be safe, pure, and, most importantly, effective. Sourced from farms across the country, our hemp is organic, non-GMO, and free from pesticides, herbicides, and chemicals. Additionally, we only use top-of-the-line equipment for safe supercritical CO2 extractions for our CBD Oil.

But knowing how we make our CBD Oil is only part of the equation. Because here at Diamond CBD, we offer you three types of CBD, all created to cater to your needs.

CBD Oil: Broad Spectrum, CBD Isolate, and Full Spectrum

Some folks prefer their CBD Oil with a hint of THC (no more than 0.3%, of course). Others enjoy nothing but pure CBD. Here at Diamond, we have something for everyone. Let’s take a look at the different types of CBD Oil we have available for you:

Full Spectrum CBD Oil – This formula provides the complete perks of CBD and the complete perks of all the elements and terpenes found naturally in industrial hemp plants. Studies show that full-spectrum CBD offers more benefits than CBD isolate by providing a large dose of the organic cannabinoids present in the plant. While it contains trace amounts of THC, full-spectrum CBD usually produces no psychoactive effects.

Broad Spectrum CBD – Similar to full-spectrum CBD, this formula offers all the benefits of natural elements and terpenes found in the hemp plant, except THC. Still offering more comprehensive benefits than CBD isolate, this formula guarantees the absence of any psychoactive effects potentially caused by the presence of THC. This worry-free solution is perfect for any wellness regime.

CBD Isolate – The purest of the three formulas, CBD isolate contains pure, isolated CBD without the presence of any other elements found in hemp. Our scientists can remove any cannabinoids, terpenes, and flavonoids from the product through a rigorous extraction process. CBD isolate offers a way to enjoy all the benefits of CBD while simultaneously avoiding interactions with other cannabinoids like THC.

No matter what type of CBD you prefer, Diamond CBD is sure to have something for you. After all, our lab nerds know what they’re doing.

How To Take CBD Oil

1. Place It Under Your Tongue

One of the preferred ways to take CBD Oil is to place a few drops under your tongue. By dropping small amounts of CBD sublingually, the compound is absorbed into the bloodstream through the blood vessels. It’s one of the fastest ways to take CBD and only second to inhaling CBD into your lungs.

How It Works: Place a few drops of CBD Oil right under your tongue and let them sit for a minute or two before swallowing. It’s an effective way for your body to absorb the compound quickly. Wait anywhere from 15 to 25 minutes as the oil bypasses the liver and stomach before the product can enter your bloodstream and pull your body into Zen mode.

2. Mix It With Food Or Drink

Many people can be put off by the taste of CBD Oil when placed under the tongue, so if you’re looking to mask the taste while still enjoying all the benefits of CBD oil, there’s a solution for you. Another way of taking CBD Oil is mixing it in with food or drinks. While you’ve probably heard of the long and winding road leading to making cannabutter—a combination of cannabis and butter— from scratch, CBD Oil in food doesn’t require hours of cooking in the kitchen.

How It Works: It’s pretty straightforward; because CBD is a fat-soluble substance, the oil in our product has already taken care of breaking it down for easy delivery into your body. You don’t have to worry about how the oil will interact with the other ingredients in your food; just add a few drops of CBD Oil into your salad dressing, smoothies, oils, or butter, and you’re done.

You’ll enjoy a hassle-free, delicious meal that will have you feeling your best within the hour. Although this method takes the CBD Oil a little longer to kick in as it makes its way through your digestive system, it also creates a more long-lasting effect than faster methods. You know what they say about good things coming to those who wait!

CBD Oil: How To Dose

An important thing to consider when taking CBD Oil is dosage. Figuring out the right amount of CBD Oil to ingest can be tricky, as it depends on several variables, including body weight, body chemistry, and what you’re using it for. For these reasons, it’s always best to start small and make your way up the dosage ladder.

Some Recommendations: Maybe start with 20mg a day and increase it by 5mg the following week. If it’s too mild for you, increase it in higher amounts.

Some research suggests that taking 0.25mg of CBD multiplied by body weight in pounds is adequate.

For those not keen on math, here’s a simple, fool-proof formula to get you where you need to be:

(0.25 x Body Weight in lbs. = Mg of CBD to be ingested)

Because all bodies are different, finding the proper dosage for you can be a trial-and-error process, but rest assured, when you find the dosage that hits just right, all your plights will certainly have been worth it.

What Are the Benefits of CBD Oil?

One of the main benefits of using CBD Oil is its distinction from THC. Unlike cannabinoids like delta 8 and delta 9, ingesting CBD Oil will leave you buzz-free and ready to take on any task without worrying about a hazy mind or impaired thinking. Research suggests that CBD Oil might help you with:

Aches and inflammation

Fine Print: The Food and Drug Administration has not approved CBD for any medical use whatsoever. The CBD sold by Diamond is not intended to cure, aid, or prevent any disease or illness.

CBD Oil vs. Delta 8 Oil (AKA To Buzz Or Not To Buzz)

As previously discussed, the primary difference between CBD Oil and delta 8 oil is the presence of psychoactive ingredients in the two substances. Both delta 8 and CBD can be used in the same ways, including droppers and mixing into food or drink. Delta 8, however, causes a mild psychotropic high, while taking CBD causes no cognitive changes in the brain.

Big Warning: Don’t operate heavy machinery while using delta 8. Don’t operate the remote control either.

Ingesting delta 8 is sure to result in a more mind-bending experience than ingesting CBD. So, CBD Oil is definitely for you if you’re looking for a cloud nine-body feel while your head remains down on earth.

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