CBD Oil For Dystonia

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Patients with dystonia who smoked medical cannabis vs those who consumed cannabis oil extract were more likely to report dystonia symptom improvement. We investigate whether cannabis and CBD oil can help to relieve the symptoms of dystonia. Here's everything you need to know. The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patients A clinical trial is planned to study the effects of cannabis on dystonia and spasticity in children with neurological

Medical Cannabis Improves Dystonia Symptoms and Alleviates Pain

In a retrospective pilot study presented at MDS 2021, researchers assessed the effect of medical cannabis treatment on symptoms of dystonia and related pain.

The following article is part of conference coverage from the International Congress of Parkinson’s Disease and Movement Disorders (MDS) Virtual Annual Meeting. Neurology Advisor’s staff will be reporting breaking news associated with research conducted by leading experts in neurology. Check back for the latest news from the MDS 2021 Virtual Annual Meeting.

Consumption of medical cannabis in adults with dystonia improves symptoms and alleviates related pain, according to study findings presented at the International Congress of Parkinson’s Disease and Movement Disorders Society (MDS) Virtual Congress 2021, held from September 17 to 22, 2021.

Previous research has found medical cannabis may help treat involuntary muscle contractions and reduce related pain in patients with dystonia by the activation of cannabinoid receptors in the basal ganglia that release γ-aminobutyric acid (GABA). This could potentially reduce severity and improve quality of life for patients with dystonia. From 2013, the Israeli Ministry of Health (MOH) has accepted the use of medical cannabis for symptomatic treatment in patients with movement disorders and related pain.

The current study aimed to assess the effect of medical cannabis on dystonia muscle activity and related pain in patients with an MOH-approved medical cannabis license.

Patients with dystonia (n=23) with an approved medical cannabis license from the MOH were contacted via telephone by researchers from the Tel Aviv University, Israel. Using a 5-point Likert scale, participants’ demographics, medical cannabis use, and treatment effects were assessed.

A total of 11 women and 12 men, with a mean age of 52.7 years, were included in the analysis. Dystonia etiologies were generalized (n=9), focal (n=6), segmental (n=5), hemidystonia (n=2), or multifocal (n=1) caused by Parkinson disease (n=6), monogenic variants (n=4), or unknown (n=13).

Participants indicated that they had been using medical cannabis for an average of 2.5±1.0 years. Medical cannabis was consumed at a mean dose of 22.6±20.1 grams per month and at a frequency of 3.3±4.3 times per day. The medical cannabis was composed of 10.6%±6.6% tetrahydrocannabinol (THC) and 8.0%±5.7% cannabidiol. Participants also indicated that they used cannabis oil extract (47.8%), smoked dried buds (43.5%), or both (8.7%).

The subjective, self-reported efficacy of medical cannabis for dystonia was 3.3/5, pain was 3.7/5, and quality of life was 3.6/5. The majority of participants (70%) also reported an improvement in sleep.

Participants who experienced more improvements to their dystonia reported using a higher THC dose than those who showed little improvement, with a positive correlation between THC dose and dystonia symptom improvement (R 2 =0.012).

Participants who smoked medical cannabis vs those who consumed the oil were more likely to report dystonia symptom improvement.

Adverse effects included dry mouth (65%), worsening mood (n=3), anxiety (n=2), anxiety with hallucinations (n=1), and suicidal ideation (n=1). Three participants stopped receiving treatment with medical cannabis due to inefficacy or adverse effects.

Study limitations included its small size and the inclusion of patients with differing dystonia symptoms, using uncontrolled dosing and administration methods. Therefore, these findings should be validated in a larger, controlled study.

“[Medical cannabis] seems to improve symptoms of dystonia and related pain. Higher daily dose of THC and smoking rather than sublingual oil are significantly more efficacious,” the researchers concluded.

Reference

Anis S, Faust-Socher A, Sverdlov D, et al. A real-life study of medical cannabis effect on adults with dystonia. Presented at: MDS Virtual Congress 2021; September 17-22, 2021. Poster 93.

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Cannabis Therapy for Dystonia [Does It Work?]

All information on this website is for general informational purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment.

Dystonia is a general term that doctors use to describe a group of movement disorders. These conditions involve uncontrollable muscle spasms and sometimes pain. They can have a massive impact on the sufferer’s quality of life, but treatment options are limited.

With medical marijuana and CBD becoming more popular, some patients are wondering whether cannabis therapy can help dystonia. We investigate in this in-depth article. But, first, let’s take a closer look at dystonia and its symptoms.

What Is Dystonia?

The term dystonia describes any one of several conditions that affect the muscles and movement. It results in uncontrollable muscle spasms and cramps, which can be extremely painful.

There are many different subtypes of dystonia, each affecting a different part of the body. They include the following:

  • Generalized dystonia (affects the whole body)
  • Myoclonus dystonia (jerking that typically affects the arms, torso, and neck)
  • Cervical dystonia (only affects the neck)
  • Blepharospasm (affects the eyes)
  • Laryngeal dystonia (affects the larynx)
  • Oromandibular dystonia (affects the lower face, jaw, and tongue)

Some types of dystonia are ‘task-specific,’ meaning that they only occur when carrying out certain activities. These activities might include writing, typing, or playing a musical instrument.

Dystonia Symptoms

In the early stages, dystonia symptoms are often mild. They may only occur in an isolated body part when performing a specific activity.

Eventually, these symptoms may progress to other body parts and become present most of the time. However, this is not always the case. Some people find that their dystonia either plateaus or improves over time.

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The most common symptoms of dystonia include:

  • Unusual twisting of the affected body part
  • Slow, repetitive movements
  • Muscle spasms and cramping
  • Tremors
  • Uncontrollable blinking

Dystonia symptoms can occur for the first time at any age. Most types of dystonia are more common in women than in men.

What Causes Dystonia?

Most experts agree that dystonia results from an abnormality in one of the brain regions responsible for movement.

For example, the basal ganglia control voluntary muscle and eye movements, among other things. This region of the brain is often dysfunctional in patients with dystonia, although other areas may also be involved.

Dystonia also appears to have a potential link with certain neurotransmitters, such as dopamine and gamma-aminobutyric acid (GABA). When the brain is unable to process these neurotransmitters effectively, their messages can become jumbled, which may lead to abnormal movement.

Most experts agree that dystonia results from an abnormality in one of the brain regions responsible for movement.

Doctors generally classify dystonia into one of three categories:

  • Idiopathic dystonia: This type of dystonia has no apparent cause.
  • Genetic dystonia: Mutations in a specific gene cause a variety of dystonia that runs in families.
  • Acquired dystonia: A kind of dystonia that occurs due to brain injury (stroke, oxygen deprivation, or physical trauma) as well as certain medications.

Dystonia often appears in tandem with other medical conditions, including Parkinson’s disease, multiple sclerosis, and cerebral palsy. Moreover, there are several dystonia triggers that can exacerbate symptoms. These include:

  • Tiredness
  • Stress
  • Alcohol
  • Caffeine
  • Activities such as talking, chewing, writing, typing, etc.

Common Dystonia Treatments (Not Cannabis)

Unfortunately, there is no cure for dystonia yet. However, there are several treatments that may help patients to manage their symptoms:

  • Botulinum toxin (Botox) injections
  • Muscle relaxants
  • Physical or occupational therapy
  • Deep brain stimulation

Deep brain stimulation involves placing a battery in the chest or abdomen. It is connected to the brain via thin wires and provides electrical stimulation to specific areas of the brain. For some patients, it can give relief from symptoms. However, others derive minimal benefit.

With dystonia treatment options so limited, it is little wonder that some patients are turning to cannabis. But does it really help?

Does Cannabis Help Dystonia?

Cannabis therapy has become widely accepted in recent years. The majority of American states now have medical marijuana programs in place, and some even allow recreational use.

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Furthermore, new research is continually shedding light on the myriad benefits of the plant. To date, most studies have focused on THC and CBD, the two most prominent cannabinoids.

THC is probably best known for its intoxicating effects but also possesses a wealth of medicinal uses. On the other hand, CBD is famous for providing many similar benefits to THC but without the high.

So far, research into cannabis for dystonia has yielded somewhat mixed results. According to a 2015 study for the journal Neurotherapeutics, there have been several reports of marijuana helping patients with dystonia. However, these are mostly single case reports, and large-scale clinical trials are lacking.

One 2002 study assessed the effects of nabilone (a synthetic form of THC) for dystonia. It found that there were no significant improvements in subjects.

Research into CBD for dystonia is slightly more promising. A 2002 study for the European Journal of Pharmacology tested CBD on hamsters with idiopathic dystonia. They found that high doses tended to delay the progression of the disease.

Another study for The International Journal of Neuroscience followed five patients with dystonic movement disorders. The participants took CBD doses between 100mg and 600mg daily for a total of six weeks.

Amazingly, all of the patients experienced improvements, ranging between 20% and 50%. However, two patients with Parkinson’s features found that doses over 300mg exacerbated their symptoms.

CBD Effects on Dystonia

The most likely explanation for CBD’s effects on dystonia is its interaction with the endocannabinoid system (ECS). This system is present in most of the body’s tissues, including the brain.

The ECS is composed of cell receptors called cannabinoid receptors (CB1 and CB2) and chemicals called endocannabinoids. These two components bind together like a lock and key to regulate a range of physiological functions. The ECS is involved in mood, appetite, and immunity, among other things.

CBD works by slowing the breakdown of endocannabinoids, thus increasing their levels in the brain.

The ECS also plays a crucial role in motor function. There is an exceptionally high concentration of CB1 and CB2 receptors in the basal ganglia of the brain. Experts have hypothesized that this is where CBD exerts its effects on dystonia.

CBD works by slowing the breakdown of endocannabinoids, thus increasing their levels in the brain. Furthermore, CBD has potent antioxidant and anti-inflammatory effects. These benefits mean that it could help to protect structures in the brain from damage in conditions like Parkinson’s disease.

However, more research is necessary to confirm how well CBD works for dystonia.

What Is the Best CBD for Dystonia?

If an individual decides to try CBD for dystonia, there are a few things to bear in mind.

If a person lives somewhere where medical marijuana is legal and has a qualifying condition, they can apply for an MMJ card. This card allows its holders to purchase high-CBD cannabis strains or CBD oil from licensed dispensaries.

The advantage of this is that it allows people to choose a product containing some THC alongside its CBD and benefit from both cannabinoids.

However, if a person lives somewhere without a medical marijuana program, they are limited to buying hemp-derived CBD oil. This product contains just trace amounts of THC and is, therefore, legal in the majority of places.

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Hemp-derived CBD is also an excellent option for anyone who does not want to deal with the intoxicating effects of THC.

The problem with many CBD products is that the market is not well-regulated. Therefore, a lot of companies are selling items that are not up to scratch. Some contain far less CBD than they should, while others could include contaminants like pesticides or solvents.

Therefore, people should be cautious when buying CBD oil for dystonia. Look for a brand that offers third-party lab reports on its website. These reports show exactly what is in each product and prove there is nothing to hide.

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There are also a huge variety of different CBD products to choose from, and picking one can be confusing. For more guidance on purchasing CBD, check out our guide to the best types of CBD products.

Cannabis Therapy for Dystonia: Final Thoughts

Dystonia is a condition that has a severe impact on a person’s quality of life. It can cause not only severe pain but also makes everyday activities a challenge. Furthermore, there are few truly effective treatments available.

Therefore, many people are turning to cannabis therapy for dystonia. There have been reports over the years of this natural medicine relieving dystonia symptoms for some people. However, hard clinical evidence is lacking, so there is no guarantee that it will work for everyone.

If a person is thinking about trying cannabis or CBD oil for dystonia, consult a medical professional first. They will advise whether it is safe or not and offer additional advice on how to manage one’s symptoms.

The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patients

A clinical trial is planned to study the effects of cannabis on dystonia and spasticity in children with neurological diseases. The clinical trial will include 40 children divided into two groups: children with spasticity and dystonia due to cerebral palsy, and children with spasticity and dystonia due to genetic neurodegenerative diseases. Each group will be randomly divided into two arms and will receive Avidekel cannabis oil 6-to-1 ratio of CBD to THC or enriched Avidekel cannabis oil 20-to-1 ratio of CBD to THC. During the study, various variables will be collected including: medication intake, spasticity, dystonia score, pain scale, restlessness scale, quality of life measures, safety tests, side effects, and an addiction test. The investigators hypothesize that cannabis consumption will reduce dystonia and spasticity in children with motor disability related to genetic neurodegenerative diseases and cerebral palsy and as a result improve motor function, non-motor functions and quality of life.

Condition or disease Intervention/treatment Phase
Spasticity Dystonia Drug: Avidekel oil Drug: Enriched Avidekel oil Phase 2

The purpose of this study is to examine the effect of two cannabis oils containing the main cannabinoid Δ9 -THC and CBD ratio of 1 to 6 and 1 to 20 (respectively), on spastic movement disorder and dystonia.

40 children will be enrolled in this study and will be divided into 2 groups:

  1. Children with spasticity and dystonia due to cerebral palsy
  2. Children with spasticity and dystonia due to genetic neurodegenerative diseases

Each group will be randomly divided into two groups:

I. Active comparator: 6-to-1 ratio of CBD to THC oil II. Active comparator: 20-to-1 ratio of CBD to THC oil

During the study the following variables will be collected:

  • Consumption of drugs medication intake
  • Spasticity grade measured using the Modified Ashworth Scale
  • Dystonia grade measured using the Barry Albright Dystonia Scale
  • Patient’s subjective report about the severity of his/her spasticity and/or dystonia
  • Pain scale
  • Restlessness scale
  • Quality of life measures: function, sleep, mood , appetite , weight
  • Safety tests: liver function, renal function, blood tests (complete blood chemistry), blood pressure, pulse, ECG
  • Side effects
  • Addiction test

The purposes of the study:

  1. Efficiency – examining the effect of cannabis on dystonia and spasticity.
  2. Examining the most effective cannabinoid ratio for the relief of dystonia and spasticity. (Δ9 -THC and CBD ratio of 1 to 6 or 1 to 20, respectively).
  3. Examining the effect of cannabis on quality of life measures (such as medication intake, mood, appetite, sleep).
  4. Safety: examination of side effects and unwanted effects of cannabis and its limitations.

Research Hypothesis: The investigators hypothesize that cannabis consumption will reduce dystonia and spasticity symptoms in children with motor disability related to genetic neurodegenerative diseases and cerebral palsy and as a result improves motor function, non-motor function and quality of life.

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