CBD oil is made from cannabis plants but won’t make you high. Still, this natural supplement could interact with some heart medicines. Find out what you need to know before you try CBD oil for heart failure. Can I Use Cbd Oil Or Hemp Oil With Lexapro And Carvedilol, Cbd Gummies For Mood Disorder cbd gummies for mood disorder Cbd Oil And Tooth Pain Cbd Ground Coffee can i use cbd oil or hemp oil with Cannabidiol (CBD) may potentiate the hypotensive effects of carvedilol — leading to side effects including lightheadedness or confusion. Caution is advised.
CBD Oil and Heart Failure
Could CBD oil ease your heart failure symptoms or help you manage your condition? This herbal supplement is sold over the counter and may be marketed with various health claims, but heart experts aren’t so sure it’s worthwhile or even safe if you have heart failure.
“Heart failure patients should know that while CBD has been touted as a wonder compound and seems to be in almost everything these days, it has never been shown to have any significant cardiovascular benefits in human studies,” says Scott Lundgren, DO, a transplant cardiologist at Nebraska Medicine in Omaha.
What Is CBD Oil?
CBD oil contains cannabidiol, an herbal liquid supplement made from the cannabis plant. It doesn’t have the same effect on the brain as THC, another compound found in cannabis that gives you a “high” when smoked or eaten, says Larry Allen, MD, associate division head for clinical affairs in cardiology at University of Colorado Anschutz Medical Campus.
“There are no known cardiovascular benefits for cannabis or cannabidiol, and there may even be some adverse effects, so people should not take these products and think that it will have positive effects on their cardiovascular health,” says Allen, who’s also co-author of the American Heart Association’s statement on all cannabis products.
In 2018, the FDA approved the first oral, purified CBD drug, Epidiolex, to treat seizures in two rare forms of epilepsy. Two synthetic versions of cannabiinds are also approved: dronabinol (Marinol, Syndros) for treatment of nausea during cancer chemotherapy and nabilone (Cesamet) to treat weight loss associated with AIDS. Marinol is synthetic THC
Some of CBD’s proven benefits in other health conditions may be intriguing to people living with heart failure, Allen says.
“Does it stimulate your appetite? Yes. Do people gain weight if they take it? Possibly true. Patients with severe heart failure do have cachexia,” or severe weight loss and muscle wasting, he says. “One could argue that people with nausea, lack of appetite, or who are losing weight could think CBD would help them. People with heart failure have a fair amount of discomfort, including edema [swelling] and somatic or pain-related issues, so you could think CBD has a role.”
But there isn’t really any evidence to prove that it will relieve heart failure symptoms or be safe to use if you have heart failure, he adds.
What We Know About CBD
Some research suggests that CBD oil may improve some heart-related symptoms:
- A very small study conducted in 2017 in England found that CBD improved resting blood pressure and blood pressure spikes related to stress in people without heart conditions.
- Various studies in animals have shown that CBD could improve vasorelaxation, or opening of arteries for better blood flow, as well as reduce inflammation. A small clinical trial from Mexico studying CBD in people with heart failure hasn’t reported any results yet.
- A large study of more than 161,000 people hospitalized for heart failure who had used marijuana found that they had, on average, a lower risk of death and shorter hospital stays. But this doesn’t necessarily mean CBD oil would have the same benefit.
It’s illegal in the U.S. to market CBD by adding it to any food or calling it a dietary supplement. Also, although the FDA has approved a few CBD drugs to treat certain diseases, don’t expect CBD sold over the counter to be safe or beneficial for heart failure, Lundgren says.
“CBD oil may not have the same properties, and it can actually cause gastrointestinal distress like diarrhea or cause decreased appetite. CBD products can include unknown ingredients and may not be accurately labeled,” he says.
When you use CBD oil, your liver breaks it down. During this process, it could interfere with your medications for heart failure or other heart conditions. “CBD has known interactions with warfarin, certain statins, calcium channel blockers, beta-blockers, and nitrates. Just because a supplement is ‘natural’ doesn’t mean that it is safe,” Lundgren says.
CBD May Have Health Risks
CBD oil must be studied in randomized clinical trials on people, not animals, before it can be considered safe or effective for heart failure, Lundgren says. Until that happens, he advises against buying or using CBD. “There is some evidence that CBD can cause liver injury as well as lead to male infertility issues. When consumed with alcohol, individuals may experience increased drowsiness, which can lead to household injuries.”
If you have heart failure, you might feel like you’re taking control of your own care by trying herbal treatments that don’t require a prescription. To be safe, talk to your cardiologist first: Ask questions about CBD oil and make decisions together about using this or any other supplement, Allen says.
“CBD products cost money and can distract you from taking prescribed treatments for heart failure that are evidence-based. They could do indirect harm to people with heart failure. . We already have a half-dozen treatments for heart failure symptoms and to help you live longer.”
Larry Allen, MD, MHS, University of Colorado Anschutz Medical Campus.
Scott Lundgren, DO, Nebraska Medicine.
FDA: “What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD,” “FDA Approves First Drug Comprised of an Active Ingredient Derived from Marijuana to Treat Rare, Severe Forms of Epilepsy,” “FDA and Cannabis: Research and Drug Approval Process.”
JCI Insight: “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.”
Oxidative Medicine and Cellular Longevity: “Therapeutic Applications of Cannabinoids in Cardiomyopathy and Heart Failure.”
Cannabis and Cannabinoid Research: “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.”
ClinicalTrials.gov: “Cannabidiol in Patients With Heart Failure in AHA/ACC Stages A-C (CAPITAL-AC).” NCT03634189.
Journal of Cardiac Failure: “Marijuana Use is Associated with Better Hospital Outcome in Patients with Acute Heart Failure: A Propensity Match Analysis from National Inpatient Database.”
Can I Use Cbd Oil Or Hemp Oil With Lexapro And Carvedilol, Cbd Gummies For Mood Disorder
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Hao Ren can i use cbd oil or hemp oil with lexapro and carvedilol thought for a while and said. In the business field, people from all walks of life must get to know them.
With Zhou Feng, of course, we have to wait until I Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol see it with my own eyes.
Isn t that the first time they met on a blind Sam Elliott Use Cbd Oil can i use cbd oil or hemp oil with lexapro and carvedilol date What s the name Looking at the other party s nameplate, Hao Ren remembered, Su Xi.
This girl has can i use cbd oil or hemp oil with lexapro and carvedilol been can i use cbd oil or hemp oil with lexapro and carvedilol in the academy for Sandy Beach Hotel can i use cbd oil or hemp oil with lexapro and carvedilol a year, why is she still so naive.
Hao Ren nodded, Yes, if you do well, Then you can i use cbd oil or hemp oil with lexapro and carvedilol can continue to raise your salary.
Anyone who can i use cbd oil or hemp oil with lexapro and carvedilol wants to provoke this rule can only be crushed by a powerful force.
Yi Xueming comforted. Guo Lin is really right.
It will be bad. Hao Ren smiled and waved his hand, You, Yuja and Wenwen were the first to follow me, but I think you are the ones who will be trained in the future, so don t let me down.
There are basically no buildings around except for some lawns.
Hao Ren s eyes lit up, and he said a little excitedly.
However, can i use cbd oil or hemp oil with lexapro and carvedilol Hao Ren was gently guiding her, and she quickly knew how to activate it.
After all, hempworx cbd oil reviews this ointment is extremely expensive, and we can can i use cbd oil or hemp oil with lexapro and carvedilol t give it away for free
This is Sandy Beach Hotel can i use cbd oil or hemp oil with lexapro and carvedilol smilz cbd gummies for sale your office, which has just been renovated.
It is your business Sandy Beach Hotel can i use cbd oil or hemp oil with lexapro and carvedilol to sell it, and we .
have no right to can i use cbd oil or hemp oil with lexapro and carvedilol interfere with the can i use cbd oil or hemp oil with lexapro and carvedilol price.
If you need anything, you can call me at any time.
Hao Ren opened a can i use cbd oil or hemp oil with lexapro and carvedilol hotel for them. Back at the company, Chen cbd oil gums Yao looked at Hao Ren and frowned, If you don t like it, we shouldn t can i use cbd oil or hemp oil with lexapro and carvedilol waste can i use cbd oil or hemp oil with lexapro and carvedilol money.
Liu Mengxue said with a smile. Lu Chengjun sat in Qin An s office and thought carefully.
Soon, the city of Yanjing came hemp bombs cbd gummies pure cbd into can i use cbd oil or hemp oil with lexapro and carvedilol view, looking at the continuous tall buildings below, the traffic was can i use cbd oil or hemp oil with lexapro and carvedilol full of traffic, the stream was endless, and it was a bustling urban scene.
It s really hard to do this business without money.
That s right, this woman makes can i use cbd oil or hemp oil with lexapro and carvedilol so much money, don t give it to me, it s not me who will give you the old age in the future, she Once married, the property belongs to others.
Thinking of these scenes, he valued Hao Ren even more.
what, one thousand Zhang Jinghong subconsciously said, but before he could finish Cbd Gummies For Pain cbd gummies for mood disorder speaking, his eyes suddenly widened, looking at Hao Ren, can i use cbd oil or hemp oil with lexapro and carvedilol he even stuttered.
Hao Ren smiled and nodded, Happy New Year, you re here just in time, can i use cbd oil or hemp oil with lexapro and carvedilol go and inform Xue Ming, Qu Shan and the others, and they will Cbd Gummies For Pain cbd gummies for mood disorder have a brief meeting in can i use cbd oil or hemp oil with lexapro and carvedilol the conference room in half an hour to clarify what we re going to do this year.
However, can i use cbd oil or hemp oil with lexapro and carvedilol the two had a very close relationship with Chen Yao, and Hao Ren was not Sam Elliott Use Cbd Oil can i use cbd oil or hemp oil with lexapro and carvedilol very relieved because he was not in Liuzhou, only Luo Song.
Hao Ren glanced at him without any explanation.
Guo Lin and you open a foreign trade can i use cbd oil or hemp oil with lexapro and carvedilol Cbd Oil And Mold Toxicity company.
This time, help me forward the who was tje football player on special datrline witth jarry smith about cbd oil article, and then go to various platforms to like and comment
Zhou Feng introduced Hao Ren with a smile. Zhou Mo and others didn t dare to speak at all.
Lu Sisi looked at can i use cbd oil or hemp oil with lexapro and carvedilol Cbd Oil And Mold Toxicity the other person s finger pointing at him, and was a can i use cbd oil or hemp oil with lexapro and carvedilol little surprised.
Now he helps with casting. As can i use cbd oil or hemp oil with lexapro and carvedilol he said that, he pet hemp oil vs cbd oil handed a document to Lu Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol Yuan.
Are you still producing in the Cbd Gummies For Pain cbd gummies for mood disorder factory Hao Ren asked curiously.
An Xiaoran However, he didn t care about the very powerful can i use cbd oil or hemp oil with lexapro and carvedilol boss that Xia Qingqing said, but looked at him can i use cbd oil or hemp oil with lexapro and carvedilol with a look of surprise, This is the ugly duckling turned into a little princess, it seems that I m going to hug your thigh well, today s coffee You invited me.
This matter cbd gummies for mood disorder Cbd Oil Affiliate Programs is very troublesome. cbd gummies for mood disorder Cbd Oil Affiliate Programs We need to explain to cbd gummy bears joint the public.
As the mayor of Liuzhou, Xu Haoyang, Naturally, the reason for this is very clear.
However, she didn t dare can i use cbd oil or hemp oil with lexapro and carvedilol to confirm that, in case it was fake, wouldn t she have put outsiders in, it wouldn t have ruined her job.
Master, let s go to practice. Yang Xuan was about to run outside can i use cbd oil or hemp oil with lexapro and carvedilol with can i use cbd oil or hemp oil with lexapro and carvedilol the Daniel.
To mix in this circle, you must learn to be exquisite.
Although the other party is very old, he is old and strong, his silver hair is very neatly groomed, and he is herbal relief cbd oil holding cbd gummies for mood disorder Cbd Oil Affiliate Programs two Cbd Gummies For Pain cbd gummies for mood disorder walnuts in his hands.
This pure natural cbd oil capsules is already a friendship price. According to his market price, 60 can i use cbd oil or hemp oil with lexapro and carvedilol million is not Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol much.
The two came to the sales office at this time.
Compared with the atmosphere and elegance of the previous necklace, it looks very small, fresh and lively.
The company is not far from the riverside, and only a few hundred meters away from the Bund.
Although it was not yet evening, he could see that there were a lot of people by the river.
Hao Ren took out a box from the desk in front of him.
Xu Yujia said spectrum health sleep medicine excitedly. It looks like a lot, but at 10,000 a day, I can t even earn can i use cbd oil or hemp oil with lexapro and carvedilol the rent.
Fan Sam Elliott Use Cbd Oil can i use cbd oil or hemp oil with lexapro and carvedilol Weihua was a middle aged man with a pair of eyes and a rather bloated figure.
As the general manager of the company, it seems that you don t have any annual salary.
He stepped forward and looked at Hao Ren, Let you go and hear, Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol believe it or not, I ll martha stuart cbd gummies find someone to Sandy Beach Hotel can i use cbd oil or hemp oil with lexapro and carvedilol kill you.
Don t worry, I ll take Xiaoran out to play tomorrow.
But Dai Shixuan rolled her eyes and said with a smile.
If he wants to make money, I think, If you send a random message, it is estimated that the people who want to invite him to class will have to wait cbd gummies for mood disorder Cbd Oil Affiliate Programs until January.
However, when he looked at Daniel s majestic body, a flash of exclamation Cbd Gummies For Pain cbd gummies for mood disorder can i use cbd oil or hemp oil with lexapro and carvedilol Cbd Oil And Mold Toxicity flashed in his eyes, How fast, I didn t see clearly, that guy just flew out, this is Mr.
We can seize this pure kana natural cbd oil review point. Whether it s justified or not, we can bite the Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol other side first, and we can ask The best team of lawyers is just a lawsuit
The next moment, she suddenly stretched out a pair of arms and gently wrapped Hao Ren s neck.
Xia Qingqing s expression froze, and she looked at her father with a puzzled face, not understanding what this meant.
He can i use cbd oil or hemp oil with lexapro and carvedilol has borrowed money from many people best quality royal cbd oil before, and everyone is willing to lend Sandy Beach Hotel can i use cbd oil or hemp oil with lexapro and carvedilol him money, not because he has developed well, but because he trusts him.
Seeing that Hao Ren was not interested, the head of the commercial bank didn t force it.
Although can cbd oil take days before it works for your body there was a bc gas safety authority little friction before, the impact was not big.
Mr. Hao, I have long admired your name. The other party said in an unfamiliar Chinese language.
Wear can i use cbd oil or hemp oil with lexapro and carvedilol this pair of shoes, it s the best match for this outfit.
Hao Ren pointed to a white bag on can i use cbd oil or hemp oil with lexapro and carvedilol the shelf, a Herm s classic, priced as high as 700,000.
I don t want to continue to cbd flintstone gummies toss, I m tired.
Hee hee, the deposit has been paid, but I can i use cbd oil or hemp oil with lexapro and carvedilol want you to come and have a look with me.
Besides, we just sing, isn t it illegal to sing Zhou Feng said with cbd gummies for mood disorder Cbd Oil Affiliate Programs a smile.
It was the guard who cbd gummies for mood disorder stopped them and informed the owners inside.
She could imagine that after today, this song will definitely explode.
Their company is on the 38th floor, and the entire floor is owned by cbd infusionz can i use cbd oil or hemp oil with lexapro and carvedilol the can i use cbd oil or hemp oil with lexapro and carvedilol Cbd Oil And Mold Toxicity Shinhwa can i use cbd oil or hemp oil with lexapro and carvedilol Company.
After speaking, he continued to walk forward.
After speaking, Hao Ren went back, got in the car, and ran towards Tianyi Building.
It seems that President Hao has also done some investigations on me, and the preparations are well done.
One shocking data, let her whast the best part of the cannnabis plant for cbd oil heart set off a storm.
I don Sam Elliott Use Cbd Oil can i use cbd oil or hemp oil with lexapro and carvedilol t believe it, you must be making some bad ideas.
You can join the remote cultural media. Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol With my presence, I believe that does cbd oil give you a buzz Mr.
You re wrong about that. It s fine to continue tossing around, but you can i use cbd oil or hemp oil with lexapro and carvedilol have to look at the right place.
The little girls nodded. After sending them off, Hao Ren will send Xu Yujia back to the house he rented before, and then go home with Chen Yao, Daniel, and Lu Sisi.
Soon, after a song was over, the final harmony between the two was even more mellow and ethereal.
Xu Sheng cbd gummies for mood disorder Cbd Oil Affiliate Programs told Hao Ren the matter as simply as possible.
Hao Ren shook his head, and everyone else laughed.
The Sam Elliott Use Cbd Oil can i use cbd oil or hemp oil with lexapro and carvedilol Yanjing affair is already can i use cbd oil or hemp oil with lexapro and carvedilol over, come back early.
Not far away, Zhou Mo and Liu Nan pretended they didn t see anything.
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Perhaps, after the changes, it may be nano enhanced hemp oil prime my body better than before.
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A group of people happily re shooted, and finally ended the shooting at night.
Needless to say, no one objected to saying that it was the can i use cbd oil or hemp oil with lexapro and carvedilol best in the country.
After all, Lu Sisi is a little girl, and letting her live here is can i use cbd oil or hemp oil with lexapro and carvedilol not good for his reputation.
Dad, when I came back this time, I happened to have something to ask you.
Therefore, the head of the commercial bank was extremely troubled.
My leader is here and still scolds you, you rubbish.
Our company currently has hundreds of employees and hundreds of products.
If can i use cbd oil or hemp oil with lexapro and carvedilol these people can survive until now, Hao Ren guessed that they all believed in Lu Chengjun s character with a high probability.
They all run to the south, and the development is far behind there.
Many people couldn t bear to go back to sleep.
Xu Yujia pouted and said on the phone. In the entire company, only a few of their old employees could joke around with Hao Ren at will.
They have come to me
Hey, this matter has already spread, the Shinhwa Company has contracted thousands of acres of land near us, and plans can cbd oil cause false positive pregnancy test to use it to grow that kind of gold and ear Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol stuff, it is said that it is the raw material of the can i use cbd oil or hemp oil with lexapro and carvedilol elf heart, and a bag costs 10,000
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All students can participate. In the boys dormitory in the school, Su Yao couldn t help being Sandy Beach Hotel can i use cbd oil or hemp oil with lexapro and carvedilol startled when he heard the news.
The other party weed gummies side effects looked can i use cbd oil or hemp oil with lexapro and carvedilol only twenty seven or eight, and seemed to be younger than cbd hemp oil skin cancer Hao Ren.
Hao Ren found it useful, so can i use cbd oil or hemp oil with lexapro and carvedilol he agreed directly.
When you get married later, don t you want to buy a jewelry store Hao Ren smiled, Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol I got married early, so what to do if I think too much.
It s relatively small, but it s barely enough to supply, and it s not as stretched as before.
And the employees of our factory and the media company.
All Hao Ren needs is constant innovation. In order for Professor Yang s verma farms cbd reviews experiment to proceed smoothly, Hao Ren specially exchanged a necessary document with the system for this purpose.
He looked at Hao Ren in astonishment, his voice stuttered.
We re not. Hao Yue looked at Su Xi can i use cbd oil or hemp oil with lexapro and carvedilol and said with a smile, Dai Shixuan, Yang Qi and others were all a little embarrassed.
The offline channel that Xueming mentioned cbd gummies for mood disorder Cbd Oil Affiliate Programs is indeed tga cbd oil a good way, and it is can i use cbd oil or hemp oil with lexapro and carvedilol also what we are currently in urgent need of.
However, her eyes suddenly lit up, You stupid, a big boss like Mr.
But the village can i use cbd oil or hemp oil with lexapro and carvedilol is full of elderly can i use cbd oil or hemp oil with lexapro and carvedilol people, and there are basically not many young people in their twenties.
At melatonin gummies strawberry the front desk of the hotel, the other party kept a warm smile and asked Hao Ren for information.
Fan Yunzhe will join the crew in a few days, so the shooting time will not be delayed
This is the gap. This is only part of it. Those rich bigwigs donate hundreds of millions each year, and several more successful alumni donate each year, which is almost billions.
Yang Hai walked around in the crowd familiarly, holding a glass of red can i use cbd oil or hemp oil with lexapro and carvedilol wine and toasting everywhere.
It was estimated that the board of directors had considered this situation, and Hao Ren cbd vape mod kit was eager raw cbd oil wholesale to agree.
At least he thought he was not qualified for it.
As the deputy director of the administration department, you actually dragged the boss out.
Lan Siying said, with a voice of undisguised confidence.
After what strength of cbd oil is the best speaking, he took out his mobile phone and called someone, who should be the owner of the stadium.
Wei Lan said with a smile, looked at the people beside him, and continued, Let me introduce you to President Hao and the generals around him
things are real. That s good. Hao Ren agreed, and drove behind can i use cbd oil or hemp oil with lexapro and carvedilol Cbd Oil And Mold Toxicity him to a clubhouse.
At the time, I just wanted to play casually.
It s like Mr. Hao, who started from scratch and built this huge business.
Naturally, there is no need to work every day to plant golden jade ears, but Hao Ren also has other arrangements for them, so it will not waste the labor.
Hao Ren joked. Is Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol it more beautiful or uglier Xiao Hongyu asked with a Cbd Gummies For Pain cbd gummies for mood disorder half smile.
I have quite a lot of resources in this area.
Hearing this, Xu Haoyang gave a wry smile, got up from the office chair, and sat on the sofa as well.
Xiao Hongyu chuckled twice and began to order food.
Today is the opening day of Xu Jing s concert, and Liuzhou City became lively very early.
This kind of thing should be very simple. can i use cbd oil or hemp oil with lexapro and carvedilol After listening to Yi Xueming s report, Hao Ren smiled and nodded, Well done.
I couldn t believe it, but can i use cbd oil or hemp oil with lexapro and carvedilol now I see it and realize that it is still too modest.
Well, let Full Spectrum Cbd can i use cbd oil or hemp oil with lexapro and carvedilol s supervise and train Tongtong together.
He said this, and the Daniel figure quietly walked to the side.
He didn t have the ability to open a branch for the time being, unless the system was upgraded to the fourth level.
Zhou Mo and the others saw the blush that had not disappeared from Chen Yao s face, and then looked at Hao Ren, who was sitting lazily on the chair, and turned their heads tacitly.
In fact, this can i use cbd oil or hemp oil with lexapro and carvedilol second group of cbd gummies for mood disorder people did not disappoint Hao Ren.
Does CBD Interact With Carvedilol (Coreg)?
Cannabidiol (CBD) may potentiate the hypotensive effects of carvedilol — leading to side effects including lightheadedness or confusion. Caution is advised.
Carvedilol is an alpha-1 adrenoreceptor blocker. It’s used in the treatment of hypertension and chronic heart failure.
While the chances these medications will interact is slim, the severity of these conditions makes it especially important for this medication to work as expected. Anything that could interfere with the ability for carvedilol to exert its effects should be avoided — including CBD.
Here’s everything you need to know.
Table of Contents
CBD and carvedilol are unlikely to interact. However, because of the shared effects on blood pressure, this combination isn’t recommended.
Speak to your doctor about using CBD before combining it with any prescription medications.
Does CBD Interact With Carvedilol (Coreg)?
Yes. CBD may interact with carvedilol.
The chances of serious interaction with this combination are low but not impossible. The most concerning side effects revolve around both substances’ ability to reduce blood pressure. Hypotension could result in lightheadedness, confusion, and fainting — all of which can become dangerous in certain situations.
CBD may interact with carvedilol in two ways:
A) CBD Enhances the Effects of Carvedilol on the Body (Agonistic Interaction)
When two items exert the same kind of effect on the body, they become agonists to each other. This causes more potency in their effects. Sometimes more potency of a medication isn’t a good thing.
Carvedilol is used to reduce blood pressure by acting on the alpha-1adrenergic receptors, which relax the blood vessels and reduce peripheral vascular resistance.
CBD, on the other hand, works on the endocannabinoid receptors, which is also involved with a reduction in blood pressure.
Therefore, taking both compounds together could result in a rapid decrease in the blood pressure, causing the user to feel dizzy and faint.
B) CBD May Slow Down Carvedilol’s Metabolism (Metabolic Competition)
Metabolic competition occurs when two or more compounds require the same enzymes for metabolism. They will compete with each other, leading to a slower metabolic rate overall.
Carvedilol gets metabolized by the CYP2D6 enzymes. CBD is metabolized by CYP2D6, too. This means consuming them together could cause them to compete.
The result could be the overaccumulation of one or both drugs in the body, delay in their removal, and increasing the risk of side effects or toxicity.
This could be prevented or lessened to a certain degree by taking the two drugs at different times of the day with enough interval between the two (around 2 hours or more).
Similar Medications: CBD & Alpha Blockers
Carvedilol is classified as both an alpha-blocker as well as a beta-blocker. CBD and alpha-blockers all share similar risks for interaction and side effects.
Here’s a list of similar medications that share a similar level of risk when combined with CBD:
- Doxazosin Mesylate (Cardura)
- Prazosin Hydrochloride (Minipress)
- Terazosin Hydrochloride (Hytrin)
Is It Safe to Take CBD & Carvedilol (Coreg) Together?
A minimum dose of both drugs, taken for a short duration, is less likely to cause many side effects. But the same cannot be said for large doses or for even minimum doses taken for a longer time.
Over long-term use, both drugs could accumulate more than normal in the body — leading to side effects. Some of these side effects can be severe and are worth trying to avoid.
You can minimize the risk further by taking CBD and carvedilol at least 2-hours apart and speaking to your prescribing physician before you begin.
No matter the dosage, you must always consult your medical practitioner before starting these two drugs together. Always be wary of any abnormal side effects, and if you encounter any health issues or side effects while taking these drugs, get medical help immediately.
Is CBD A Viable Alternative to Carvedilol (Coreg)?
CBD has a blood pressure-lowering ability. However, this differs from the mechanism of action of carvedilol and may not be enough for severe cases.
CBD works on the CB1 receptors of the endothelium by releasing nitric oxide that can dilate blood vessels, lowering blood pressure .
CBD has been shown to reduce blood pressure in users who also have increased heart rates .
CBD has antioxidative and anti-inflammatory properties as well , which offers some indirect hypotensive effects by combating inflammation in the arterial system.
CBD may be a good alternative for reducing blood pressure in mild cases, such as prehypertension. However, it may not be sufficient for people diagnosed with high blood pressure.
What is Carvedilol (Coreg)?
Carvedilol is an antihypertensive belonging to the alpha-blockers class. It has properties of both alpha-1 adrenoreceptor blocker and beta-adrenoceptor blocker. Coreg is one of its most commonly used brands.
Carvedilol is used in the treatment of hypertension, mild to severe chronic heart failure, hypertension, and left ventricular dysfunction.
It’s an FDA-approved drug and sold as a prescription-only drug in most countries.
Carvedilol (Coreg) Specs:
|Trade Name||Coreg, Caditone, Cadmos, Carca, Carca-CR, Cardivas, Cardivas, Carelol, Carloc, Carzec, Caslot|
|Classification||Alpha-Blockers, Beta-adrenoceptor blocker|
|Interaction With CBD||Agonistic, Metabolic competition|
|Risk of Interaction||Moderate|
Other Names For Carvedilol (Coreg)
Carvedilol is sold under many different names. All share the same risk and potential interactions.
Other names for Carvedilol include:
What Does Carvedilol (Coreg) Do?
Carvedilol is used in the treatment of coronary heart failure, left ventricular dysfunction following myocardial infarction, and hypertension.
It’s an alpha-1 adrenoceptor blocker that also possesses the properties of a beta-adrenoceptor blocker. This is attributed to its two forms, the S(-) enantiomer and the R(+) enantiomer. Its S(-) enantiomer is a beta-adrenoceptor blocker, and the R(+) enantiomer has both forms of beta and alpha-1 adrenoceptor blocker.
The double ability of carvedilol can decrease side effects while using low-dose combination drugs in comparison to a single heavy dose of one drug.
Carvedilol can decrease rapid or increased heart rate through beta-adrenergic antagonism, and it can lower blood pressure through alpha-1 adrenergic antagonism. Carvedilol can act on alpha-1 adrenergic receptors and relax the smooth muscle in the vasculature. This causes a reduction in peripheral vascular resistance, which leads to an overall reduction in blood pressure.
It has a long duration of action and should not be stopped abruptly as it may exacerbate coronary artery disease.
At high doses, it may even be able to block calcium channels. It also has antioxidant properties, which can prevent oxidation of low-density lipoprotein and its uptake into coronary circulation.
Carvedilol has a half-life of 4 to 7 hours, and it reaches peak concentration at 4 to 7 hours. Carvedilol can cause defects in the newborn if used during pregnancy, and there is no information about its effects on lactation.
Side Effects of Carvedilol (Coreg)
- Atrioventricular block
- Chest pain
- Decrease in heart rate
- Raynaud phenomenon
- Skin rash
- Increased sleepiness
- Weight gain
Key Takeaways: Is it Safe to Take Carvedilol (Coreg) With CBD?
CBD and carvedilol carry a mild to moderate risk of interaction with each other. The main concern is that CBD may cause blood pressure to drop too low when used in combination with prescription antihypertensives like carvedilol. Side effects of this would involve dizziness, confusion, and fainting. These side effects can be dangerous while driving, operating heavy machinery, or moving up or down stairs.
It’s always wise to speak with your doctor before taking supplements alongside prescription medications.
You can also further minimize the risk of side effects by separating the dose of carvedilol and CBD by 2 hours.