Hey everyone! I have a 9 year old son with ADHD, and he takes 20 mg of Vyvanse each morning. It is working very well for him, but he is metabolizing through it very quickly, and it is out of his… CBD may interact antagonistically with lisdexamfetamine (Vyvanse), a stimulant, and cause side effects. Find out if they’re safe to use together.
ADHD med in morning and CBD oil in af. – CHADD’s ADHD Pare.
Hey everyone! I have a 9 year old son with ADHD, and he takes 20 mg of Vyvanse each morning. It is working very well for him, but he is metabolizing through it very quickly, and it is out of his system by 3:30. I was interested in possibly giving him some CBD oil in the afternoon to help with his symptoms in the afternoon/evening, but I’ve read here that some are saying that CBD oil should not be given with stimulant meds. Now, is that still the case if it isn’t given until after the meds have left the system? Is it okay to give it to him after the meds have worn off to help with the remainder of the day?
I appreciate your kind responses.
I have been given my son a low dose of CBD Oil in the morning and afternoon. Our doctor still has not prescribed us medication (that’s another discussion). We have seen a lot improvement with his anxiety but not much with the symptoms of ADHD. If you don’t mine me asking, approximately how many milligrams of CBD Oil do you give your son?
How do you know which is CBD oil to give?
HELLO! I JUST JOINED! I’M NOT SURE IF YOU’VE FINALLY PUT YOUR CHILD ON CBD OIL, BUT WE ARE STARTING THE ISOLATE SINCE THE BROAD FULL SPECTRUM CBD OIL HAS TRACE AMOUNTS OF THC, WHICH CAN AGGRAVATE ANXIETY MORE SINCE IT SPEEDS UP HEART RATE PLUS AT A YOUNG AGE IT IS BETTER TO AVOID THE THC BUT EVENTUALLY AS THEY GET OLDER IT SHOULDN’T BE MUCH OF AN ISSUE! THESE ARE THE DAYS WE ARE GUINEA PIGS SINCE WE DO NOT FULLY KNOW THE LONGTERM AFFECTS OF CBD OIL! THEY SEEM TO THING IT CAN SLOW DOWN RESPONSE BUT EVERYONE IS DIFFERENT PLUS THE BODY GOES THROUGH WITHDRAWALS WHICH IS SCARY! IT JUST DEPENDS ON YOUR SITUATION HOW SEVERE IT IS! MINE IS PRETTY SEVERE SO I HAVE EXHAUSTED OPTIONS! MY SON IS ON PROTANDIM WHICH IS A HOLISTIC OPTION! HE HAS DEFINITELY GOTTEN BETTER & COULD CONTINUE TO BUT HIS ADHD IS THROUGH THE ROOF & PROTANDIM AT THIS MOMENT IN TIME ISN’T AS AFFECTIVE! IT MAY BE DOWN THE ROAD BUT IN THE MEANTIME WE ARE STRUGGLING! I HOPE YOUR CHILD HAS IMPROVED! WISHING YOU THE BEST
Bring your concerns about the Vyvanse to your son’s doctor and talk about changes in dose or a different medication or supportive intervention. That is a better choice and a more effective one for your son than including CBD oil. It may be a relatively easy fix and one that the doctor can better assist you with.
There is not any evidence that CBD oil will treat ADHD symptoms, which are related to executive function. There is limited research into CBD oil for anxiety, which has been done in small groups with adults, only. There is no indication that it would be effective in treating ADHD symptoms in children.
Also, there hasn’t been research into possible interactions between CBD and other medications. So you run a chance of a medication interactions, especially since CBD oil is not regulated and you can’t be sure of what you actually have.
Furthermore, using CBD oil could make it difficult for you to get good treatment for your son in the future, as many professionals will decline to work with people or families that us cannabis products, including CBD oil.
You might find our Q&A “Will ADHD Symptoms Improve with Marijuana?” at bit.ly/nrcmarijuanaQA to be helpful.
The National Resource Center on ADHD
Our son is also on 20 mg vyvanse and some days it’s gone before 3. We’ve chosen to give a “booster” in the afternoon. It’s just 5 mg of Ritalin and it’s so much better. It took a couple of weeks to establish but makes such a huge difference in keeping evenings happier.
We are also doing a booster of our medication so he can get through homework, sports and the evening.
Vyvanse (like many stimulants) do have a short lifespan, which isn’t always bad for the long term health of our kiddos, but can be problematic for our kids “surviving” their last class of the day, completing any/all homework effectively/efficiently (without you and/or them wanting to rip your hair out), or participation in afterschool activities/sports. My son has ADHD (diagnosed at 5) and Autism Spectrum Disorder (diagnosed at 9) and has been on Vyvanse since he was 6 (was on Adderol at 5, but the weight loss and lack of sleep was too destructive). When my son began gymnastics, we quickly realized it wasn’t just a matter of being able to complete homework and focus during sports, it was also a SAFETY issue for him and his teammates since gymnastics can be dangerous if you’re not focused and impulsive. We opted to give him a fast-acting 5ml dose of Adderol (or was it Ritalin? It was a tiny oval blue tablet) afterschool (between ages 10-12) on the afternoons he had gymnastics practice (3+ days a week). It made a HUGE difference! I cannot impress upon you enough the benefits of discussing these concerns with his pediatrician/neurologist and if they don’t take you seriously, seek a second opinion elsewhere. As much as our family discourages the use of prescription medications, there are times and needs for them. I’ve seen so many kids who not only failed to succeed but also suffered social, emotional, and relationship detriments because it can take such a toll on them to “keep it together” to behave/act/appear like all the other neurotypical kids. I’d love one day for my son to not be on meds, as he’s getting older, we’re finding him taking more weekends off of meds (his choice) and we’re slowly seeing an increase in his ability to manage (he’s nearly 15 now) the symptoms of his ADHD/ASD, but it has taken a LOT of work at home, school, therapies, ADHD/ASD-specific summer camps (Talisman Programs) and kind/constructive conversations for him to become more self-aware so as to better negate, prevent, or diminish the challenges he faces from ADHD/ASD. At the end of the day, I believe our ADHD/ASD kids are quite brilliant, unfortunately they are on the outside looking in and sometimes feel trapped in their own mind/bodies. It takes so much effort to fit in with neurotypicals, it’s taken me years to personally wrap my own head around it. But I believe their unique qualities can help them succeed in ways that are not as effortless for neurotypicals. Companies like Microsoft are seeking individuals like our kids, because they can hyperfocus and see/do things that blow the rest of us out of the water Best of luck to you and your son. It does get easier, and some behaviors/challenges diminish, go away, or are replaced by different ones, but with your support, it does improve!
Does CBD Interact With Lisdexamfetamine (Vyvanse)?
CBD may interact antagonistically with lisdexamfetamine (Vyvanse), a stimulant, and cause side effects.
The risk of this interaction is mild to moderate.
Lisdexamfetamine (Vyvanse) is a neuro-stimulant used to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder. It belongs to the amphetamine family of drugs.
Cannabidiol or CBD , a cannabinoid with many health-promoting properties, may behave antagonistically with or slow down the metabolism of lisdexamfetamine and cause side effects.
Are the two safe to take together?
Table of Contents
Does CBD Interact With Lisdexamfetamine (Vyvanse)?
Yes, CBD is likely to interact with Vyvanse — however, the severity of this interaction is low and unlikely to result in any lasting side effects.
There are two primary ways CBD can interact with stimulant drugs like lisdexamfetamine (Vyvanse).
1. Decreased Effects (Antagonistic Interaction)
CBD may counteract some of the stimulating effects of Vyvanse — preventing it from doing its job effectively.
Antagonistic interaction occurs when two drugs act in opposite ways. If taken together, one drug could interfere and even stop the actions of the other drug, causing the second drug to become less effective.
Lisdexamfetamine is a stimulant drug that enhances brain activities such as awareness, wakefulness, emotional regulation, attention, learning, and memory.
In contrast, CBD is a neuromodulator that exerts its effects on the central nervous system (CNS) via multiple pathways that are not yet fully understood. CBD is used as an anticonvulsant and anxiolytic. These effects may happen through its actions on endogenous systems such as neuronal inhibition and intracellular calcium modulation.
Because of their opposite effects, they are likely to cancel each other out, and CBD may reduce the activity and efficacy of lisdexamfetamine.
2. Slowed Elimination (Metabolic Inhibitor)
CBD may interfere with the body’s ability to metabolize Vyvanse — leading to elevated levels. This could lead to an increased risk of side effects from the medication.
Drugs are metabolized in the body due to the actions of the cytochrome P450 class of enzymes. When two medications that need similar enzymes for metabolism are taken together, they compete for the enzyme. This action could result in slowing down the metabolism of both drugs.
Lisdexamfetamine is extensively metabolized and eliminated by the CYP2D6 enzyme. While CYP2D6 also metabolizes CBD, CYP3A4 is the major enzyme responsible for its metabolism. However, CBD has inhibitory effects on CYP2D6, which can slow down the metabolism of lisdexamfetamine. This could cause lisdexamfetamine to accumulate within the body and cause unintentional side effects.
Other Names for Lisdexamfetamine
Lisdexamfetamine is sold under different names. All of them have the same base ingredient and have similar possible interactions.
Other names for lisdexamfetamine include:
Similar Medications: CBD & Stimulants
Lisdexamfetamine (Vyvanse) is a stimulant. CBD and stimulants all share similar risks for interaction and side effects.
Some of the medications that share similar risks when combined with CBD are:
- Amphetamine (Adderall, Adzenys ER, Mydayis)
- DextroamphetamineSulfate (Zenzedi, Dexedrine)
- Methylphenidate (Ritalin)
- Atomoxetine (Strattera)
- Modafinil (Provigil, Nuvigil)
Is It Safe to Take CBD & Lisdexamfetamine (Vyvanse) Together?
Yes, CBD is unlikely to pose any danger when taken with Vyvanse (when used in responsible doses).
However, CBD may negate some of the beneficial effects of the drug, causing it to be insufficient for managing the symptoms it was prescribed for.
Because the conditions Vyvanse is used to treat aren’t life-threatening, there’s a low chance of this effect resulting in any serious consequences.
The main indication for lisdexamfetamine is ADHD, and taking the two drugs together may make symptoms of ADHD worse due to decreased efficacy of lisdexamfetamine.
Always consult your prescribing physician first before you start these drugs, and never adjust the dose or stop taking Vyvanse on your own.
Is CBD a Viable Alternative to Lisdexamfetamine (Vyvanse)?
CBD is not considered a viable alternative to lisdexamfetamine (Vyvanse).
However, there are a few conditions where CBD may work for which lisdexamfetamine is indicated or even work as an adjunct to it.
Researchers had initially believed that CBD could worsen the symptoms of ADHD, but studies have not found any evidence to support this. In fact, some research shows positive results using CBD for ADHD .
Depending on the severity of the problem, maybe CBD could be enough to help, but it’s always best to talk to your doctor before changing or adjusting medications.
CBD may also help patients who binge eat but, again, the research lacks anything conclusive .
One of the most significant differences between CBD and lisdexamfetamine is that the latter is more likely to result in dependence and withdrawal symptoms. Therefore, there is a chance that lisdexamfetamine can be misused and overdosed.
What Is Lisdexamfetamine (Vyvanse)?
Lisdexamfetamine (Vyvanse) is a derivative of the drug amphetamine and belongs to a class called central nervous system stimulant.
Vyvanse is the brand name of the drug lisdexamfetamine. It is a prodrug of the psychostimulant d-amphetamine.
It’s used mainly to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder. It’s a prescription medicine approved by the FDA that works by increasing the production and decreasing the metabolism of the neurotransmitters like dopamine, serotonin, and norepinephrine.
Lisdexamfetamine (Vyvanse) Specs:
|Trade Name||Vyvanse, Tyvense, Elvanse|
|Classification||Central nervous system stimulant|
|CYP Metabolism||CYP2D6 enzyme|
|Interaction With CBD||Antagonistic and Metabolic Inhibition|
|Risk of Interaction||Mild|
What Does Lisdexamfetamine (Vyvanse) Do?
Lisdexamfetamine (Vyvanse) can increase the attention span and decrease restlessness in children and adults with ADHD.
It’s also used for binge-eating disorders because of its appetite suppressant qualities.
Lisdexamfetamine for ADHD
ADHD is a disorder of the brain where the person tends to lack the ability to concentrate, has difficulty controlling impulsive behaviors, and is overly active.
The exact mechanism of ADHD is not completely understood. However, it is linked to genetics, exposure to environmental risks, and toxins during pregnancy, among other things.
People with ADHD may have a higher concentration of dopamine transporters in the brain. This means these transporters remove dopamine from the brain too fast, causing a decreased level of dopamine in the brain. There also tend to be low levels of serotonin and norepinephrine in the brain in those with ADHD.
Once consumed, lisdexamfetamine turns into dextroamphetamine and L-lysine. This drug has two optical isomers called trace-amine associated receptor 1 (TAAR1) and vesicular monoamine transporter 2 (VMAT2). It can enter monoamine neurons and release monoamine neurotransmitters like dopamine, serotonin, and norepinephrine from their storage places in presynaptic neurons.
These neurotransmitters help in alertness and increase and maintain concentration and motivation. It can also prevent the reuptake of these neurotransmitters from the synaptic cleft but does not bind to the sites of the reuptake of norepinephrine and dopamine.
Lisdexamfetamine for Binge Eating
The exact action of lisdexamfetamine (Vyvanse) on binge eating disorders is unknown. In binge eating disorders, food may trigger the brain to make more dopamine, the hormone that makes us feel pleasure.
It’s possible that lisdexamfetamine raises the dopamine levels in the brain and sustains it enough so that the person does not consume more food than necessary. However, this has not been proven yet.
Lisdexamfetamine may have less abuse potential compared to other amphetamines but can still cause dependence.
Side Effects of Lisdexamfetamine (Vyvanse)
Symptoms vary from minor to severe. It’s good to know what can happen so you can inform your doctor if you experience any.
- Loss of appetite
- Stomach upset
- Increased blood pressure
- Increased heart rate
- Blurred vision
- High possibility of substance abuse
If you’re using lisdexamfetamine and suspect you’re becoming dependant on it, speak to your doctor immediately. They can help you reduce the dose gradually to avoid withdrawal.
Lisdexamfetamine withdrawal symptoms include:
If you want to stop taking lisdexamfetamine and shift to CBD, you should talk to your doctor first. They may recommend slowly tapering this drug to avoid or to reduce the withdrawal symptoms.
Key Takeaways: Is It Safe to Take Lisdexamfetamine (Vyvanse) With CBD?
CBD can decrease the effects of lisdexamfetamine (Vyvanse) and even slow down its metabolism from the body, causing more unintended side effects.
This interaction is considered mild and low risk — but caution is still advised.
If you experience any adverse effects after taking CBD with Vyvanse, seek medical attention immediately.