CBD Oil And Prednisone


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No, it is not safe to use CBD oil while taking Prednisone simultaneously. CBD can inhibit CYP3A in the body. Read more. Studies show that as many as 30% of patients will not respond to steroid treatments, requiring more information on CBD as a replacement for steroids… Studies have shown that CBD possesses potential therapeutic benefits that may help with some symptoms or conditions where prednisone is indicated. Learn more.

Can you safely take CBD oil with Prednisone?

I’ve heard that CBD can interact with many drugs. Are there interactions with Prednisone and CBD oil?

Joel Taylor (Thursday, August 12, 2021):

Both CBD oil and Prednisone are inhibitors of the cytochrome P450 enzyme CYP3A, which means that taking both of them together would result in them having to compete for metabolism. What this means is that the interactions with CBD oil and Prednisone could be dangerous, potentially leading to increased side effects from both. If you are on Prednisone or any other medication, you should talk to your doctor before deciding to try CBD oil as well. Additionally, give it a few hours in between doses to minimize adverse reactions as much as possible.

Osasere Okunloye (Thursday, August 12, 2021):

Studies show that CBD can interact with Prednisone by inhibiting the same enzyme (Cytochrome P450 enzyme CYP3A) as prednisone, and using both of them together may decrease glucocorticoid clearance and increase side effects of Prednisone. Before taking CBD with prednisone or any other medication, you should seek professional advice from a doctor. Reply Follow Share Avik Das Wednesday, January 12, 2022 No, it is not safe to use CBD oil while taking Prednisone simultaneously. CBD can inhibit CYP3A in the body, but Prednisone is also known to inhibit CYP3A in the body. Therefore, using them together might give good results in glucose clearance, but facing systemic side effects is inevitable. It is always best to consult a doctor before using CBD oil with Prednisone.

What Are Some Benefits Of Taking CBD Oil?

CBD oil interacts with your Endocannabinoid system to help control your physiological responses. Taking CBD oil can help you de-stress, and relax, such as via Cannabotech’s Relax drops and Beauty Sleep drops.

CBD oil can also help relax your muscles after a workout, try Unwind Tablets.

CBD and steroids: can CBD offer the same benefits as corticosteroids?

Studies show that as many as 30% of patients will not respond to steroid treatments, and at the present time there are 629 clinical studies on CBD, some pertaining to CBD and steroids

Corticosteroids (steroids) such as cortisone, prednisone, and hydrocortisone are prescribed to patients regularly. In some cases, these types of drugs are used to reduce inflammation. This makes them beneficial for individuals diagnosed with respiratory tract infections or allergic reactions. Steroids can also be helpful for those who are diagnosed with chronic inflammatory conditions such as asthma and various forms of arthritis. In the conversation of CBD and steroids, can CBD offer the same benefits for individuals who have issues with steroids?

Other times, steroids are the treatment of choice for conditions impacting the immune system. Since they are immunosuppressive, they reduce the body’s tendency to erroneously attack itself. Autoimmune diseases that often respond to steroid treatments include lupus, inflammatory bowel disease, and sarcoidosis.

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Although steroids can provide patients relief from these types of issues and conditions, the problem in using them is they don’t always come without negative side effects.

Harmful effects of corticosteroids

In 2017, BMJ published a population-based cohort study. In this study, data was collected from more than 1.5 million adults who submitted private insurance claims between the years 2012-14. Approximately one in five (21.1%) of these patients received at least one oral corticosteroid prescription during this time.

Within 30 days of receipt of this prescription, patients had elevated rates of sepsis, venous thromboembolism, and fracture. Sometimes it took as long as 90 days for these risks to return to their pre-steroid level.

According to another 2017 study, this one published by BMJ Open Quality, almost two-thirds of the 22 subjects studied (64%) had at least one adverse reaction. Of the patients, 41% reported experiencing two or more harmful effects.

Among the negative reactions noted were:

  • weight gain (45%)
  • osteoporosis (18%)
  • cataract (18%)
  • hypertension (14%)
  • diabetes (14%)
  • dyspepsia (9%)
  • adverse psychological effects (5%)

This same study noted that long-term corticosteroid use can have negative consequences as well. Five years after the study initiated, two patients developed secondary hypertension. One developed diabetes, one a cataract, and one had adrenal insufficiency. Additional studies support this finding, adding other long-term effects such as gastrointestinal and hepatic issues.

It’s often said that the cure shouldn’t be worse than the treatment. Therefore, some patients are turning to alternate treatment methods such as CBD.

CBD for inflammation, immunity, and pain relief

The cannabidiol CBD is found within the hemp plant that has been linked to a variety of health benefits. Inflammation, immunity, and pain relief are three that are most relevant in the replacement of steroid use when discussing CBD and steroids.

For example, one animal model involved rats with arthritic knee joints. After having transdermal CBD gel applied for four days, the test subjects had “significantly reduced joint swelling.” There were also indications that they experienced less pain.

An article published in the journal Cannabis and Cannabinoid Research in March 2020 adds that CBD has positive effects on both the innate and adaptive immune systems. Like steroids, it acts as an immunosuppressive, controlling immune response through actions such as T cell induction.

Still other pieces of research connect CBD with easier management of difficult to treat pain. Since some of the conditions that steroids are typically used to treat involve pain as a symptom — like arthritis and lupus — CBD can potentially assist with this as well. CBD research is booming, and more human trials are underway since certain types of CBD were made legal with the Hemp Farming Act of 2018.

CBD and steroids: resistance and studies

Another factor to consider when it comes to CBD and steroids in terms of replacement is that some people are resistant to steroids’ effects.

The University of Bristol, UK, indicates that as many as 30% of patients will not respond to steroid treatments. This can make their conditions more difficult to control and treat. In situations such as this, CBD may be a suitable alternative, providing patients relief when other drugs don’t seem to work.

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The one factor that makes it difficult to know exactly what effect CBD has on patients who would typically be prescribed steroids is, until passage of the Farm Bill, industrial hemp was illegal. As a result, a number of studies in this area have been conducted on animals versus humans. This has made it harder to identify CBD’s full effects.

At this moment in time, there are 629 clinical studies that are hoping to provide more information in this area. As each one is completed, we will begin to learn more about this cannabinoid and how it influences inflammation, immunity, and pain. Once we do, we will also know about whether it is, in fact, a suitable replacement for prescription steroid drugs.

CBD Oil and Prednisone – August 2022

Does CBD interact with prednisone, and if so, are there risks that should cause concern?

Prednisone is a prescription drug used to provide relief for inflamed areas of the body. It is also indicated to treat conditions, such as inflammation (swelling), severe allergies, arthritis , asthma, eye or vision problems, blood or bone marrow problems, and stomach or bowel problems (1 ) .

Moreover, doctors prescribe prednisone to help patients with lupus, skin conditions, endocrine problems, kidney problems, ulcerative colitis, adrenal problems, and flare-ups of multiple sclerosis.

Prednisone is a corticosteroid, or a cortisone-like medicine or steroid. This drug works on the immune system to help relieve swelling, redness, itching, and allergic reactions.

However, this medicine may cause changes in mood or behavior for some patients. Symptoms to watch for include depression, trouble with sleeping , a false or unusual sense of well-being, mood swings, and personality changes while taking this medicine (2 ) .

Can CBD Be Taken With Prednisone?

Taking CBD along with prednisone could either decrease the effects of cannabidiol or increase the amount of prednisone entering the bloodstream.

Whenever one takes CBD or any medicine, it passes through the digestive system to the liver, where an enzymatic pathway, called the cytochrome P450 (CYP450) family of enzymes, metabolizes or breaks down the substance ingested.

Liver enzymes CYP450 process about 60% of all medications. One of these, CYP3A4, metabolizes prednisone to make it available to the body (3 ) .

Studies have demonstrated that CBD strongly inhibits the activity of CYP3A4 liver enzymes (4 ) .

Meanwhile, prednisone is a weak inducer of CYP3A4 (5 ) . Still, prednisone may increase how quickly the liver breaks down CBD when they are taken in combination.

In particular, the effects of taking CBD along with prednisone could either decrease the effects of cannabidiol or increase the amount of prednisone entering the bloodstream.

The increased prednisone concentration can amplify the drug’s many side effects and raise the risk of severe symptoms, such as dizziness or fainting, blurred vision, irregular or pounding heartbeat, increased thirst or urination, irritability, and unusual tiredness or weakness (6 ) .

Thus, medical experts advise those taking CBD and prednisone to be cautious with this combination (7 ) .

Can CBD Replace Prednisone?

N o study explicitly says CBD can be used in place of prednisone. However, studies have shown that CBD possesses many potential therapeutic benefits that may help with some symptoms or conditions for which prednisone is indicated.

Prednisone is sometimes prescribed for bone marrow problems , which is important for the health of blood cells . Meanwhile, studies have shown that CBD promotes the structural health of bones .

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The effect of CBD on bones was also demonstrated by a 2015 study that investigated the properties of cannabidiol concerning bone-related conditions. Data showed that CBD led to an improvement in fracture healing (8 ) .

Like prednisone, CBD can help with skin conditions. A study published in the journal Trends in Pharmacological Sciences has suggested the existence of a functiona l endocannabinoid system (ECS) in the skin and implicated it in various biological processes (9 ) .

CBD impacts the TRPV-1 and GPR55 receptors (10 ) . Both receptors are found in the skin and play a role in pain signaling and inflammation.

CBD has also been shown to help with mood swings, depression, dizziness, and sleeping difficulty, which may be the side effects from taking prednisone.

A study published in the Journal of Psychopharmacology found that CBD may decrease anxiety levels in individuals with a social anxiety disorder (SAD).

Results indicated that, relative to placebo, CBD was associated with significantly decreased subjective anxiety (11 ) .

In another study, results showed that CBD could theoretically induce rapid-acting antidepressant-like effects and enhance neurotransmission (12 ) . Neurotransmission is the process of communication between nerve cells.

In a 2019 study published in The Permanente Journal , sleep and anxiety scores were measured in human subjects, and the findings showed that CBD could hold benefits for anxiety-related disorders (13 ) .

Meanwhile, CBD’s antiemetic properties, which prevent nausea and vomiting, are incredibly helpful.

A 2014 review from the European Journal of Pharmacology established the potential of cannabis to limit or prevent nausea and vomiting from a wide range of causes (14 ) .

More importantly, the powerful anti-inflammatory properties of CBD could help with some of the same disorders that prednisone treats.

CBD’s anti-inflammatory characteristics have been shown in several human and animal studies, like that of a 2014 study published in the Journal of Clinical Investigation and a 2012 research conducted by authors from the Department of Pathology, School of Veterinary Medicine in the University of São Paulo, Brazil (15 ) .

Other studies have demonstrated that the anti-inflammatory and immunosuppressive actions of CBD may be of use in treating rheumatoid arthritis and the associated pain (16 ) .

Meanwhile, research published in the Free Radical Biology & Medicine Journal by George Booz of the University of Mississippi Medical Center showed that CBD, which may interact with the endocannabinoid system, is a promising prototype for anti-inflammatory drug development (17 ) .


CBD “is generally well tolerated with a good safety profile,” the World Health Organization (WHO) states in a critical review (18 ) .

Still, it is not clear how much to take or how often a person should use it for any particular problem.

High doses of CBD may also interact with other medications, such as blood thinners, antidepressants, and immune suppressors (19 ) .

Thus, individuals should be cautious when supplementing their existing medications with CBD.

Do not take other pharmaceuticals unless they have been discussed with a medical professional.

More importantly, before using CBD as a remedy for specific symptoms or conditions, consult with a doctor experienced in cannabis use for advice.

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